I had squished my SI joint in rehearsal for a show and was put on a serious amount of ibuprofen to deal with the inflammation and pain at the base of my spine. After a few months I was told before I did physical things like gardening or running, to take a couple of ibuprofen beforehand and that would decrease the discomfort of the activity.
About a mile from home, running with my two dogs, like flicking a light switch I couldn’t breathe. I was wheezing and checking my fingernails for blue tinge as I walked to take my dogs home and get to a medical centre. As it turned out, my allergy history made me prone to ibuprofen causing asthma (exercise induced in my case). So that was the end of that.